Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19–deficient mice
نویسندگان
چکیده
1 Department of Cell Biology, 2 Genetic Engineering and Functional Genomics Group, Horizontal Medical Research Organization, and 3 Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan 4 Department of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan 5 KAN Research Institute Inc., Kyoto Research Park, Chudoji, Shimogyo-ku, Kyoto 600-8317, Japan 6 Section of Developmental Neurophysiology, Ozaki Institute for Integrative Bioscience, National Institute of Natural Sciences, Okazaki 444-8787, Japan 7 Department of Molecular Cell Biology, Institute of DNA Medicine, The Jikei University School of Medicine, Nishi-Shinbashi, Minato-ku, Tokyo 105, Japan
منابع مشابه
Tight junctions in Schwann cells of peripheral myelinated axons
Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. Claudin-19-deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peri...
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Claudins form a family of transmembrane tight junction proteins that play a key role in control and selectivity of paracellular transport. Mutations in claudin-19, which is expressed in kidney, retina, and myelinated peripheral neurons, were identified in familial hypomagnesemia with hypercalciuria and nephrocalcinosis, a hereditary disease causing renal Mg(2+) and Ca(2+) wasting. Here, we stud...
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Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet. 3.3.3 mb eGFP under the control of claudin k promoter specifically and strongly labels the processes of Summary 1 1 SUMMARY Myelination is a key step in vertebrate evolution: oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) tightly wrap their cytoplasmic processes...
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Tight junctions (TJs) form physical barriers in various tissues and regulate paracellular transport of ions, water, and molecules. Myelinating Schwann cells form highly organized structures, including compact myelin, nodes of Ranvier, paranodal regions, Schmidt-Lanterman incisures, periaxonal cytoplasmic collars, and mesaxons. Autotypic TJs are formed in non-compacted myelin compartments betwee...
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